University of Wisconsin–Madison

Biochem 800 – Practical Nuclear Magnetic Resonance Theory

spinecho fidEvery fall semester, Dr. Milo Westler, Director of NMRFAM, teaches Biochem 800 – Practical Nuclear Magnetic Resonance Theory (2 credits) at UW-Madison on Tuesdays and Thursdays at 11:00am in Room 2221 in the DeLuca Biochemical Sciences Building. Scope of the course includes study of multipulsed, multinuclear, and multidimensional NMR spectroscopy, emphasis on the vector and product, and operator formalisms for the analysis of modern pulse sequences. Course format is lecture and discussion and grades will be based on participation and problem sets. Topics to be covered: The Vector Paradigm; Coherence and Magnetization; Radio Frequency (Rf) Excitation; Chemical Shifts; Signal Detection; Fourier Transformation; Coherence Transfer Pathways and Phase Cycling; Pulsed Field Gradients; Scalar Coupling; Product Operator Formalism; Coherence Transfer; Isotope Directed Editing; Two-Dimensional NMR; Multi (>2)-Dimensional NMR; 1H, 13C, and 15N Triple Resonance 3D and 4D NMR; Pulse Concatenation and Sequence Optimization; Relaxation. Prerequisites are introductory NMR (e.g., organic chemistry), basic trigonometry, elementary physics, and physical chemistry.

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