National Magnetic Resonance Facility at Madison

Capabilities

Sample Scheduling Procedures

Project proposals from all users are assessed for scientific merit and technical feasibility through the same review process. NMRFAM utilizes iLab for reserving instrument time. Scheduling protocols prioritize projects with high scientific impact and are designed to maximize instrument usage and access for all users to cutting-edge NMR instrumentation. For spectrometers with multiple probes or shared between solution and solid-state NMR, configurations will be set and reviewed on a monthly basis. These decisions will be based on user demand for different configurations while minimizing down time for transition and striving to limit the wait from request to spectrometer time.

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More on Sample Scheduling Procedures

Spectrometer time is scheduled for the highest field and highest demand instruments first. Requests for high field NMR time must justify the need for high-field and demonstrate sample quality.

Within each spectrometer calendar, the schedule is set in the following order:

  1. Remote users traveling to NMRFAM to perform experiments so that travel plans can be accommodated. This is rare (a few times a year) due to the excellent remote data collection capabilities at NMRFAM.
  2. Service requests that were denied (despite scientific merit and feasibility) in the previous month simply due to a lack of available spectrometer time or incompatible configuration.
  3. Technology development projects that require coordinated scheduling of NMRFAM staff and spectrometer time, have confirmed need and justification for the specific spectrometer and experiment, and have demonstrated sample quality. No more than 50% of spectrometer usage, limited by staff capacity.
  4. The highest scientific priority and impact service projects for each individual instrument configuration. Experiments with long acquisition times that cannot be interrupted by maintenance scheduled first. Shorter experiments are filled in to the schedule to maximize spectrometer usage.
  5. Lower scientific priority service and collaboration projects are scheduled last.

Within tiers 4-5 (≈ 50% of spectrometer usage), every effort is made to accommodate time-sensitive requests due to unstable samples or data needed for grant proposals or publication revisions with short deadlines.

Solution State NMR Schedules and Capabilities

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Fleckvieh (Bruker Avance III HD, 900 MHz)

Photo of Fleckvieh NMR magnet• 5 mm cryoprobe triple resonance probe (1H(13C/15N) (Default)
• 50:50 solution and solids beginning Mar. 2020
• Fleckvieh Schedule

Gelbvieh (Varian VNMRS DD, 800 MHz)

Photo of Gelbvieh NMR magnet• 5 mm cold probe (1H(13C/15N) (Default)
• Gelbvieh Schedule

Telemark (Bruker Avance III HD, 750 MHz)

Photo of Telemark NMR magnet• 5 mm Cryoprobe TXI (1H/13C/15N) Z-axis gradient (Default)
• Telemark Schedule

Jaulan (Varian VNMRS 600 MHz)

Jaulan• 5 mm cold probe (1H/13C/15N) Z-axis gradient (Default)
• Jaulan Schedule

Kurgan (Bruker Avance III HD, 600 MHz)

• 1.7 mm cryoprobe TXI (1H/13C/15N) (Default)
• Automatic sample changer (5×96 samples)
• Kurgan Schedule

Kerry (Bruker Avance III HD, 500 MHz)

Kerry• 5 mm cryoprobe TXO (13C(1H/15N) Z-axis gradient (Default)
• Automatic sample changer (5×96 samples)
• Kerry Schedule

Solid State NMR Schedules and Capabilities

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Fleckvieh (Bruker Avance III HD, 900 MHz)

Photo of Fleckvieh NMR magnet• 5 mm cryoprobe triple resonance probe (1H(13C/15N) (Default)
• 50:50 solution and solids beginning Mar. 2020
• Fleckvieh Schedule

Aryshire (Varian VNMRS 750 MHz wide bore)

Photo of Ayrshire 750 magnet• Quintuple resonance (five channel, HFXYZ) console
• Low noise high power preamplifiers
• Extended variable temperature range
• Customized probes: 3.2 and 1.6 mm Varian/Phoenix designs
• Configurations include HFXY (broadband), HPCN, HPCD, HPDN, HCDN
• Please inquire about your requirements for collaborative projects
• Aryshire Schedule

Vosges (Bruker Avance III HD 600 MHz)

vosges

• 3.2 mm Bruker Efree CPMAS (HCN). Up to 25 kHz MAS rate. (Default)
• Static (PISEMA) BioProbe
• Coming soon: 1.6 mm Phoenix NMR Low-E HXY CPMAS. Up to 40 kHz MAS rate.*
• Coming soon: 3.2 mm Varian T3 HXY. Up to 25 kHz MAS rate.*
• Vosges Schedule*probes indicated with asterisks are compatible with all SSNMR 600 MHz consoles (Oxford 600/51AS magnets) 250 ms CORD mixing data of UCN-GB1 at 13.333 kHz MAS

Ribeye (Varian InfinityPlus, 600 MHz)

spectrometer

• CURRENT CONFIGURATION: 3.2 mm Varian T3 HXY in HCN mode.
• 3.2 mm Varian T3 HXY in HCN mode. Up to 25 kHz MAS rate.* VT range -50 to +50 C.
• 1.6 mm Varian T3 HXY. Up to 40 kHz MAS rate.*
• 1.6 mm Phoenix NMR Low-E HXY CPMAS. Up to 40 kHz MAS rate.*
• Ribeye Schedule*probes indicated with asterisks are compatible with all SSNMR 600 MHz consoles (Oxford 600/51AS magnets) CC 2D spectrum of GB1, 250 ms DARR mixing, collected with 3.2 mm T3 HXY probe, 13.333 kHz MAS rate, May 10, 2020

Taurus (Varian InfinityPlus, 600 MHz)

Taurus
• 3.2 mm Varian T3 HXY. Up to 25 kHz MAS rate. (Default)*
• 1.6 mm Varian T3 HXY. Up to 40 kHz MAS rate.*
• 1.6 mm Phoenix NMR Low-E HXY CPMAS. Up to 40 kHz MAS rate.*
• Taurus Schedule

*probes indicated with asterisks are compatible with all SSNMR 600 MHz consoles (Oxford 600/51AS magnets)