Photo of NMRFAM Space

National Magnetic Resonance Facility at Madison (NMRFAM) is a resource that aims to expand the frontiers of biomolecular NMR spectroscopy in solution and the solid state, to ease access for scientists to state-of-the-art spectroscopic methods, and to disseminate technologies broadly to the user community.

NMRFAM provides access to high field (600-900 MHz) solution and solid-state NMR instrumentation and expert staff to assist researchers who would like assistance in experimental design, data acquisition or data analysis. Please contact us with your project ideas and instrumentation needs.

Although NMRFAM is currently operating under essential operations only, we are actively contributing to the COVID-19 NMR project and are establishing scheduling procedures for other requests as part of the UW campus phased reopening.  Current policy is here and updates will be provided as additional activities are approved.

 

WHAT’S NEW AT NMRFAM

May 29, 2020:  900 MHz SSNMR!  NMRFAM has completed installation of the Phoenix NMR 1.6 mm quadruple resonance probe for HC and HCN modes.  Many additional configurations for HFXY, HFX and HXY are available. Example data and more information at Fleckvieh.

May 2020:  NMRFAM has partnered with the COVID-19 NMR project to determine protein and RNA structures from SARS-CoV-2 and study the inherent flexibility and dynamics that contribute to the interactions with other proteins and small molecules.  Prof. Rienstra is serving on the governing board and Prof. Henzler-Wildman is coordinating the local experimental efforts.  Please contact us if you would like to contribute to this project or have questions.  See example data so far collected @NMRFAM for NSP7 and NSP8.

 April 2020:  Welcome Chad Rienstra! Prof. Chad Rienstra joined UW-Madison Biochemistry in January and now is full-time in Madison  He and Prof. Katie Henzler-Wildman are now (effective May 17, 2020) co-directors of NMRFAM as Prof. John Markley transitions to emeritus status.  As part of Prof. Rienstra’s startup, upgrades are in progress with new magnets, spectrometers and probes customized for magic-angle spinning solid-state NMR spectroscopy applications.  Please check the instrumentation page for updates as these capabilities become available to users, and let us know if you would like to request special configurations for your experiments or discuss work plans for your projects.

April 2020:  Thank you, John Markley! Prof. John Markley established NMRFAM in 1986. The world class facility that NMRFAM has become is a tribute to his vision and leadership over the past 30+ years. Prof. Markley has made many contributions to the field of NMR and we celebrate his accomplishments and wish him well as he transitions into emeritus status in May.