NMRFAM-Home-opt

NMRFAM operations during the COVID-19 pandemic – Essential operations only

UW-Madison is currently operating under essential operations ONLY. This means that NMRFAM is not operating under normal procedures.

  • Standard NMR calendars are suspended while research operations are restricted. You will not be charged for time that you have reserved but cannot use because of COVID-19. If you currently have time reserved, please contact Lai Bergeman (lai.bergeman@wisc.edu) and Milo Westler (milo@nmrfam.wisc.edu) to confirm cancellation of your time or to discuss the possibility of running your experiment if it meets the guidelines below.
  • Limited research operations are ongoing. Samples can be changed only when staff are already in the facility to perform essential operations. No experiments requiring frequent sample changes or hands-on staff time in the facility will be performed. Long-running experiments may be run through remote operations in consultation with NMRFAM staff. If you have a sample already at NMRFAM and wish to collect additional data, this is your chance! Please contact Lai Bergeman (lai.bergeman@wisc.edu) and Milo Westler (milo@nmrfam.wisc.edu) if you would like to discuss experiments that meet these requirements.
  • There will be no entrance to any part of the facility except for essential staff. No staff will be present except during essential procedures (cryogen fills, maintenance, etc.). Staff will be available through email and are happy to discuss project planning, data analysis, etc.
  • Shipping and receiving is currently operating at a very reduced capacity. Please do NOT ship your precious, isotopically-labeled samples to us because we cannot guarantee prompt receipt and proper handling.
  • There will be no drop-off sample service on Tuesdays and Thursdays.
  • The June NMRFAM workshop will most likely not be held on-site. Stay tuned for further information regarding a possible virtual workshop.

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The National Magnetic Resonance Facility at Madison (NMRFAM) is a resource for biomolecular nuclear magnetic resonance (NMR) spectroscopy and related techniques that aims to expand the frontiers of biomolecular NMR spectroscopy through technology, research, and development programs.

| Become an NMRFAM Collaborator | Become an NMRFAM User |

Learn more about how we can help advance your research in the following areas:

Research Center Focus

What is NMRFAM

The National Magnetic Resonance Facility at Madison (NMRFAM) is a Biomedical Technology Research Resource (BTRR), a National Institutes of Health (NIH) / National Institute of General Medical Sciences (NIGMS)-funded, shared instrumentation laboratory located at the University of Wisconsin-MadisonDepartment of Biochemistry.

In addition to assisting users in their research, NMRFAM actively seeks collaborative projects that present substantial technical challenges and serve to drive the development of the Center’s Technology Research and Development (TR&D) Projects.

NMRFAM’s Current TR&D Projects

  • Automation in NMR data collection, spectral analysis and assignment, and structure determination of small- and moderate-sized proteins and RNA molecules.
  • Determination of the structure, dynamics, and functional properties of challenging proteins and nucleic acids and their complexes by NMR and SAXS approaches.
  • NMR-based studies of metabolomics and natural products including LC-MS solid-phase extraction of molecules of interest.

NMRFAM’s Grants and Funding Sources

Change NMRFAM spectrometer access password

Become an NMRFAM User
Contacts | Map | Policy
Instrumentation w/Rates
Pulse Programs
Remote Access to NMRFAM
Spectrometer Live Calendar
Sundial (Request NMR Time)
Software Tools
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Biochemistry 800 – Practical Nuclear Magnetic Resonance Theory

Biochemistry 801 – Biochemical Applications of Nuclear Magnetic Resonance

“The Future of NMR-Based Metabolomics, Current Opinion in Biotechnology (2017), pp. 34-40

Documents on the use of the Bruker-Axs Nanostar,SAXS instrument and analysis of SAXS data are now available.

NMRFAM-SPARKY Distribution – the popular NMR analysis program SPARKY recompiled (including updated python and Tcl/Tk) with incorporation of PINE-Sparky, enhancements to import/export to the structural analysis program CYANA, and other useful python extensions.

ADAPT-NMR Enhancer: Complete Package for Reduced Dimensionality in Protein NMR Spectroscopy

RNA-PAIRS: RNA Probabilistic Assignment of Imino Resonance Shifts

PACSY, a Relational Database Management System for Protein Structure and Chemical Shift Analysis

Donate to NMRFAM

US tax-deductible donation can be made to NMRFAM
Please write check payable to “UW Foundation, Account 112152802”

And mail to:
Attn: Sarah Lynn Traver Saunders
Associate Administrative Program Specialist
University of Wisconsin-Madison
433 Babcock Drive
Madison, WI 53706
Tel: 608-265-2507 or email

1st: Lai Bergeman
Rm 171; Phone 262-3173
2nd: Milo Westler
Rm B160; Phone 263-9599
3rd: Paulo F. Cobra
Rm B224; Phone 265-3303
4th: Marco Tonelli
Rm B160; Phone 263-9493
5th: John Markley
Rm 171A; Phone 263-9349