November 2024
NEWS & UPDATES
- Lakenvelder, the Network for Advanced NMR 1.1 GHz solid-state NMR (SSNMR) Bruker NEO spectrometer located at NMRFAM, has been fully installed and is performing at a very high level. We are looking forward to working with new users to leverage this unique resource. Please see more details on the probe capabilities below and contact us if you have projects that would benefit from 1.1 GHz. Click here to download steps to submit a time request.
NEW USER INFORMATION
- NMRFAM provides access to high field (500-900 MHz) solution and solid-state NMR instrumentation and a team of expert staff to assist researchers in experimental design, data acquisition or data analysis. Please contact us with your project ideas and spectrometer needs. Please visit the NMRFAM website for more information.
- Solution NMR spectrometers (Fleckvieh 900 MHz, Gelbvieh 800 MHz, Telemark 750 MHz, Kurgan 600 MHz, Dexter 600 MHz, Kerry 500 MHz) are all equipped with 5 mm triple resonance HCN cryoprobes. Additional HPCN and HFCN quad cryoprobes are available at 600 MHz. A 1.7mm cryoprobe is also available at 600 MHz. SampleJet with capacity for up to 500 samples is available at 500 MHz and 600 MHz.
- Varian SSNMR spectrometers (Ayrshire 750wb, Taurus 600, Ribeye 600) feature a customized version of OpenVNMRJ 3.1 with advanced automation capabilities. These systems are optimized for 1.6 mm and 3.2 mm Varian and Phoenix probes, including HCN, HFCN, HPCN and other broadband configurations.
- Bruker SSNMR spectrometers (Lakenvelder 1.1 GHz, Girolando 900 MHz, Vosges 600 MHz) offer unique performance with emphasis on high performance 13C detection at high and ultra-high field.
- For a full comparison of 13C detection sensitivity among the NMRFAM solids probes, please see Han et al. JMR 2024: https://doi.org/10.1016/j.jmr.2024.107709
SOLID STATE NMR SPECTROMETERS at NMRFAM:
- Vosges: 600 MHz Bruker Avance III (TopSpin 3.6) with Bruker 3.2 mm E-FREE HCN, Bruker static and Phoenix 1.2 mm, 1.6 mm, and 3.2 mm HFXY. Vosges offers flexibility to operate in several modes and is reconfigured among different types of experiments on a regular basis to provide best flexibility for user projects.
- Taurus: 600 MHz Varian Direct Drive II (Open VnmrJ 3.1) quadruple resonance HFXY console with Varian 1.6 mm T3 HXY and Phoenix 1.6 mm HFXY probes. Taurus is primarily used for 1H-detected 3D and 4D fast magic-angle spinning experiments requiring lengthy periods of signal averaging.
- Ribeye: 600 MHz Varian Direct Drive (Open VnmrJ 3.1) triple resonance HXY console with Varian 3.2 mm T3 HXY probe and Phoenix 1.2 mm and 1.6 mm HXY. Ribeye is currently being used for several probe and spectrometer console development projects.
- Ayrshire: 750 MHz wide bore Varian Direct Drive (Open VnmrJ 3.1) quintuple resonance HFXYZ console with several MAS probes including Varian Balun 3.2 mm, BioMAS 3.2 mm, FastMas 1.6 mm HXY, 1.6 mm HFXY and HXYZ, and Phoenix 1.6 mm and 2.5 mm HFXY. This instrument specializes in high sensitivity 13C-detected 3D/4D experiments and 19F REDOR.
- Girolando: 900 MHz Bruker Avance NEO (TopSpin 4.4) with Bruker 0.7 mm HCN, Phoenix 1.2 and 1.6 mm HFXY, Blackfox 1.6 and 2.5 mm HCN/HPC/HC.
- Lakenvelder: 1.1 GHz Bruker Avance NEO (TopSpin 4.3) with Phoenix 1.6 mm and 1.2 mm HFXY, Blackfox 1.6 mm HCN/HPC/HC, Bruker 0.7 mm HCN.
SOLUTION STATE NMR SPECTROMETERS at NMRFAM:
- Kerry: 500 MHz Bruker Avance III with 5 mm TCO HCN cryoprobe and samplejet
- Kurgan: 600 MHz Bruker Avance III with 5 mm TCI HCN or 1.7mm TCI HCN cryoprobes and samplejet
- Dexter: 600 MHz Bruker Avance III with 5 mm QCI HFCN cryoprobe or 5 mm QCI HPCN cryoprobe
- Gelbvieh: 800 MHz Varian VNMRS with 5mm TCI HCN cryoprobe
- Fleckvieh: 900 MHz Bruker Avance III with 5 mm TCI HCN cryoprobe
Donate to NMRFAM:
US deductible donations can be made to NMRFAM. Please write check payable to:
UW Foundation, Account 112152802 and mail to:
Attn: Associate Administrative Program Specialist (Bria Judkins)
University of Wisconsin-Madison
Department of Biochemistry
433 Babcock Dr.
Madison WI 53706
Recent Publications:
Substrate dependence of transport coupling and phenotype of a small multidrug resistance transporter in Pseudomonas aeruginosa. Wegrzynowicz AK, Heelan WJ, Demas SP, Mclean MS, Peters JM, Henzler-Wildman KA. J Bacteriol. 2024 Oct. PMID:39258918.
Enhancing Spectrometer Performance with Unsupervised Machine Learning. Harding BD, Hu Z, Hiett A, Delaglia F, Henzler-Wildman KA, Rienstra CM. J Phys Chem B. 2024 Oct. PMID:39395040.
A complete 3D-printed tool kit for Solid-State NMR sample and rotor handling. Olson MA, Han R, Ravula T, Borcik CG, Wang S, Viera PA, Rienstra CM. J Magn Reson. 2024 Sep. PMID 39178738
Tetrakis(trimethylsilyl)silane as a standard compound for fast spinning Solid-State NMR experiments. Han R, Paterson AL, Milchberg MH, Pang Y, Vanderloop BH, Rienstra CM. J Magn Reson. 2024 Aug. PMID:39178749
Cross polarization stability in multidimensional NMR spectroscopy of biological solids. Harding BD, Barclay AM, Piehl DW, Hiett A, Warmuth OA, Han R, Henzler-Wildman K, Rienstra CM. J Magn Reson. 2024 Aug. PMID: 38991266
Low power supercycled TPPM decoupling. Garg R, DeZonia B, Paterson AL, Rienstra CM. J Magn Reson. 2024 Aug. PMID: 38991267
Higher Order Structure Differences Among Insulin Crystalline Drugs Revealed by 2D heteronuclear NMR. Wang S, Rienstra CM, Chen K. ChemMedChem. 2024 Aug. PMID:39116305
Solid-State NMR 13C sensitivity at high magnetic field. Han R, Borcik CG, Wang S, Warmuth OA, Geohring K, Mullen C, Incitti M, Stringer JA, Rienstra CM. J Magn Reson. 2024 Aug. PMID: 38991265
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